Software plays an important role in the safety of today’s systems and is increasingly used to create system with variants in form of product families or systems with online-reconfiguration in a cost-efficient manner. Therefore, the required hazard analysis has to consider not only a concrete system and its embedded software but also the different software configurations.We present several extensions to an existing component-based hazard analysis approach. At first, our approach permits to identify the optimal design variant w.r.t. the probabilities of the considered hazard. As the number of variants in a product family is often enormous, our approach secondly supports the hazard analysis of a whole product family at once. The analysis identifies the variant or combination of variants with the worst hazard probability. Finally, we show that also the hazards of systems with online-reconfiguration can be analyzed using the presented approach.